Telomere binding proteins are proteins that bind to the telomer regions of chromosomes. These proteins that bind to the telomer ends prevent the cell from perceiving the DNA ends as broken, so that cell division will not be inhibited and the cell does not commit suicide. These proteins form two groups as double stranded and single stranded DNA binding. In each cell division, telomeres in chromosome three are slightly reduced by telomerase enzymes. It has been found that this telomere shortening rate increases when the amount of telomere binding protein in the cell is increased experimentally. Based on these findings, it has been suggested that the telomer-binding protein may serve to attract telomerases to telomeres. Telomer-binding protein has been shown to work together with TRF2, Werner protein (WRN) and Bloom syndrome protein (BLM). As a common feature in telomere binding proteins binding to double stranded DNA, it has been found to have a myb-like region that allows them to bind to DNA. Another group of telomere binding proteins is bound to single-stranded DNA in TG chain telomes. The oligonucleotide / oligosaccharide / oligopeptide linker (OB) sequence of these proteins is common. Mouse TRF2 was found to be associated with the core membrane. It has been suggested that TRF2 serves to bind the telomeres to the core membrane.

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