Prazosin is a sympatholytic drug used in the treatment of high blood pressure, anxiety, and post-traumatic stress disorder (PTSD) with the trade name Minipress, Vasoflex, Lentopres and Hypovase. Alpha-1 is an α1 blocker with an adrenergic receptor antagonist. These receptors are found in vascular smooth muscle cells responsible for the vasoconstrictive effect of norepinephrine, and are also found in the central nervous system. As of 2013, Prazosin is non-patent in the US and the FDA has approved at least one generic manufacturer.

Prazosin in oral use has minimal activity in cardiac functions due to alpha-1 receptor selectivity. But when prazosin starts to show its effect; Pulse and contractility rises to maintain blood pressure, it is called reflex tachycardia. The effects of prazosin lowering the blood pressure occur with a long time. After a certain time, pulse and contractility begin to decrease and blood pressure drops. The antihypertensive activity of prazosin is the secondary route for the treatment of high blood pressure. Prazosin is also useful in the treatment of urinary incontinence due to prostate enlargement. Prevents alpha-1 receptor receptors that cause the prostate and the urethra to contract. However, it is not the first choice in the treatment of hypertension or prostate enlargement. It is a treatment option in patients with both diseases occurring simultaneously. This drug has been shown to be effective in treating severe nightmares in children and people with post-traumatic stress disorder. Use for this purpose is made with lower doses than antihypertensive doses. This drug is also recommended in Indian red scorpion sting (Hottentotta Tamulus)

First dose syncope. Dizziness, headache, drowsiness, lack of energy, weakness, palpitations and nausea (frequency: 4-10%). Less frequent (1-4%) side effects include vomiting, diarrhea, constipation, edema, orthostatic hypotension, dyspnea, syncope, dizziness, depression, irritability, rash.

Orthostatic hypotension and syncope is a weak method that the body uses without adrenergic receptors to control active alpha-blood pressure. Patients using paposin should be told to stand up slowly when standing up. Sudden lifts may be fainted due to poor baroreflex effects. It may cause nasal obstruction due to vasodilatation in the nasal mucosa.

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